Oxidative derivatization of V-type nerve agents as a tool for their structural elucidation by liquid chromatography/tandem mass spectrometry.
Tamar Shamai YaminMoran MadmonHagit PrihedMerav BlancaAvi WeissbergPublished in: Rapid communications in mass spectrometry : RCM (2021)
In contrast to the ESI-MS/MS spectra of the V-type nerve agents, which exhibited mostly/only information on the amine-containing residue, the ESI-MS/MS spectra of the V-type nerve agent N-oxides revealed ions indicative of both the alkyl phosphonothiolate and the amine parts, enabling their reliable structural elucidation.
Keyphrases
- ms ms
- liquid chromatography tandem mass spectrometry
- simultaneous determination
- peripheral nerve
- magnetic resonance
- ultra high performance liquid chromatography
- high performance liquid chromatography
- ionic liquid
- magnetic resonance imaging
- healthcare
- solid phase extraction
- density functional theory
- single cell
- computed tomography
- health information
- social media
- tandem mass spectrometry
- gas chromatography mass spectrometry