A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain.
Takayuki SakaiAya OgataHiroshi IkenumaTakashi YamadaSaori HattoriJunichiro AbeShinichi ImamuraMasanori IchiseMari TadaAkiyoshi KakitaHiroko KoyamaMasaaki SuzukiTakashi KatoKengo ItoYasuyuki KimuraPublished in: EJNMMI radiopharmacy and chemistry (2024)
C]BIIB021 and in vitro and in vivo imaging HSP90α/β. However, the quantification of HSP90α/β is complicated by the presence of radiometabolites in the brain and the potential to be a substrate for p-glycoprotein. Further efforts are needed to develop radioligand suitable for imaging of HSP90α/β.
Keyphrases
- heat shock protein
- heat shock
- high resolution
- resting state
- white matter
- computed tomography
- heat stress
- deep learning
- functional connectivity
- cerebral ischemia
- positron emission tomography
- living cells
- risk assessment
- machine learning
- quantum dots
- human health
- photodynamic therapy
- pet imaging
- climate change
- fluorescence imaging