Blockade of sodium-glucose co-transporters improves peritoneal ultrafiltration in uraemic rodent models.
Marina VorobiovBoris RogachevReut RiffCidio ChaimowitzEndre Z NeulanderAnna BasokAlla ShnaiderAmos DouvdevaniYosef-Shmuel HavivPublished in: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis (2023)
Our study suggests that peritoneal non-type 2 SGLTs facilitate glucose diffusion from dialysis solutions, and we propose that limiting glucose reabsorption by specific SGLT inhibitors may emerge as a novel strategy in PD treatment to enhance UF and mitigate the deleterious effects of hyperglycaemia.