Total Synthesis of Cryptotrione.

Mao-Yun LyuZhuliang ZhongVanessa Kar-Yan LoHenry N C WongXiao-Shui Peng

Published in: Angewandte Chemie (International ed. in English) (2020)

The total synthesis of cryptotrione (1) was enabled by substrate-controlled diastereoselective construction of the bicyclo[3.1.0]hexene framework through platinum-catalyzed enyne cycloisomerization and Lewis acid induced polyene cyclization to construct the abietane-type tricyclic diterpene skeleton. The stereogenic tertiary carbon center in the side chain was installed in a diastereodivergent manner by conjugate addition reactions.

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