Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.

Haya Al-SulaitiIlhame DibounMaha V AghaFatima F S MohamedStephen AtkinAlex S DömlingMohamed A ElrayessNayef A Mazloum

Published in: Journal of translational medicine (2019)

This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality.

Keyphrases

insulin resistance
type diabetes
high fat diet induced
metabolic syndrome
adipose tissue
high fat diet
skeletal muscle
polycystic ovary syndrome
glycemic control
ms ms
weight loss
weight gain
big data
machine learning
physical activity
clinical trial
study protocol
artificial intelligence