EZH2 identifies the precursors of human natural killer cells with trained immunity.
Chen ZhangJie YinJian ZhengJun XiaoJiajian HuYudong SuKaichen ZhouYingchi ZhangXuzhen ZhangHong ZhangQian SunYang WangWenwen YuFeng WeiQiang ZhaoLong LiXiu-Bao RenPublished in: Cancer biology & medicine (2021)
Our work revealed human NK heterogeneity in the induction of trained immunity, identified the precursor subset for trained NK cells, and demonstrated the critical role of EZH2 in the induction of trained immunity in human NK cells.