Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells.

José Ignácio Gonzalez SolariEduardo Cremonese Filippi-ChielaEmily Salles PilarVitória NunesEsteban Alberto GonzalezFabrício FigueiróCristiano Feijó AndradeFábio Klamt

Published in: BMC cancer (2020)

Cisplatin alone induced the highest levels of ICD-associated DAMPs, so that its combination with immunotherapy may be a promising therapeutic strategy in NSCLC.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
small cell lung cancer
oxidative stress
high glucose
drug induced
advanced non small cell lung cancer
endoplasmic reticulum stress
signaling pathway
tyrosine kinase
stress induced
epidermal growth factor receptor