The effect of aging on the repeated-dose liver micronucleus assay.

Miyuki ShiganoHironao TakasawaShuichi Hamada

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2021)

These results suggest that the liver MN inducibility decreases with age. Therefore, we recommend the use of rats of 6 weeks of age at start of administration to reliably detect the liver MN induction in the RDLMN assay.

Keyphrases

high throughput
metal organic framework
gestational age
single cell