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Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor.

Rongxia LiuElke H HeissBirgit WaltenbergerTina BlaževićDaniel SchachnerBaohong JiangVladimir KrystofWanhui LiuStefan SchwaigerLuis M Peña-RodríguezJohannes M BreussHermann StuppnerVerena M DirschAtanas Georgiev Atanasov
Published in: Molecular nutrition & food research (2018)
RAME represses PDGF-induced VSMC proliferation in vitro and reduces neointima formation in vivo. These results recommend RAME as an interesting compound with VSMC-inhibiting potential. Future metabolism and pharmacokinetics studies might help to further evaluate the potential relevance of RAME and other spice-derived polyphenolics for vasoprotection.
Keyphrases
  • smooth muscle
  • cell proliferation
  • signaling pathway
  • diabetic rats
  • human health
  • current status
  • cell cycle
  • oxidative stress
  • climate change
  • vascular smooth muscle cells