Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor.
Rongxia LiuElke H HeissBirgit WaltenbergerTina BlaževićDaniel SchachnerBaohong JiangVladimir KrystofWanhui LiuStefan SchwaigerLuis M Peña-RodríguezJohannes M BreussHermann StuppnerVerena M DirschAtanas Georgiev AtanasovPublished in: Molecular nutrition & food research (2018)
RAME represses PDGF-induced VSMC proliferation in vitro and reduces neointima formation in vivo. These results recommend RAME as an interesting compound with VSMC-inhibiting potential. Future metabolism and pharmacokinetics studies might help to further evaluate the potential relevance of RAME and other spice-derived polyphenolics for vasoprotection.