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Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology.

Dmitry SakharovDiana MaltsevaEvgeny KnyazevSergey NikulinAndrey PoloznikovSergey ShilinAncha BaranovaIrina TsypinaAlexander Tonevitsky
Published in: BMC systems biology (2019)
When integrated into a multi-tissue platform, Caco-2 cells may aid in generating insights into complex pathophysiological processes, not possible to dissect in conventional cultures.
Keyphrases
  • induced apoptosis
  • high throughput
  • cell cycle arrest
  • single cell
  • circulating tumor cells
  • endoplasmic reticulum stress
  • signaling pathway