Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4+ T cells through differential DNA methylation, explaining a substantial proportion of heritability.

Eunji HaSo-Young BangJiwoo LimJun Ho YunJeong-Min KimJae-Bum BaeHye-Soon LeeBong-Jo KimKwangwoo Kim Sang-Cheol Bae

Published in: Annals of the rheumatic diseases (2021)

Our findings revealed that the methylomic changes, driven by RA heritability-explaining variants, shape the differential expression of a substantial fraction of DEGs in CD4+ T cells in patients with RA, reinforcing the importance of a multidimensional approach in disease-relevant tissues.

Keyphrases

rheumatoid arthritis
dna methylation
disease activity
single cell
gene expression
ankylosing spondylitis
copy number
interstitial lung disease
genome wide
systemic lupus erythematosus
rna seq
systemic sclerosis