Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome.

Felipe TroncosoHermes SandovalBelén IbanezDaniela Lopez Francisca Bustos Juan Carlos TapiaPedro SandañaEsthefanny Escudero-Guevara Francisco J Nualart Eder Ramírez Robert W Powers Manu Vatish Hiten D Mistry Lesia O KurlakJesenia AcurioCarlos Escudero

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

Offspring from preeclampsia exhibited diminished brain cortex angiogenesis, associated with lower circulating VEGF/PlGF/KDR protein levels, impaired brain endothelial migration, and dysfunctional assembly of F-actin filaments. These alterations may predispose to structural and functional alterations in long-term brain development.

Keyphrases

resting state
functional connectivity
endothelial cells
white matter
vascular endothelial growth factor
early onset
cerebral ischemia
high fat diet
type diabetes
pregnant women
multiple sclerosis
skeletal muscle
case report
insulin resistance
brain injury
amino acid
protein protein
subarachnoid hemorrhage