Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model.

Marielza Andrade NunesMariana ToricelliNatalia Mendes SchöweHelena Nascimento MalerbaKaris Ester Dong-CresteDaniela Moura Azevedo Tuma FarahKatia De AngelisMaria Claudia IrigoyenFernand GobeilTânia Araujo VielHudson Sousa Buck

Published in: Pharmaceuticals (Basel, Switzerland) (2020)

Our results indicate that the kallikrein-kinin system plays a beneficial role in Alzheimer's disease through B2R activation. The use of B2R agonists could, therefore, be a possible therapeutic option for patients diagnosed with Alzheimer's disease.

Keyphrases

mouse model
end stage renal disease
cognitive decline
chronic kidney disease
newly diagnosed
peritoneal dialysis
mild cognitive impairment