Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System.
Yuehong WangYuwen WangFadong LiXinying ZhangHongzhu LiGuangdong YangChangqing XuCan WeiPublished in: Cardiovascular drugs and therapy (2020)
The protective role of spermine on energy metabolism disorder is based on higher CaSR protein level and lower gp78 activation, pointing to the possibility that spermine can be a target for the prevention and treatment of DCM.