Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes.

Lea A TölkenAntje D PaulikatLana H JachmannAlexander RederManuela Gesell SalazarLaura M Palma MedinaStephan MichalikUwe VölkerMattias SvenssonAnna Norrby-TeglundKatharina J HoffMichael LammersNikolai Siemens

Published in: Journal of biomedical science (2024)

Our data demonstrate that strains, which harbor covR/S mutations, interfere with IL-18 and IL-8 responses in monocytic cells by utilizing the caspase-8 axis. Future experiments aim to identify the underlying mechanism and consequences for NSTI patients.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
end stage renal disease
endothelial cells
cell death
ejection fraction
escherichia coli
signaling pathway
prognostic factors
staphylococcus aureus
current status
machine learning
big data
cell proliferation
candida albicans