6-Paradol Alleviates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Inhibiting AKT/mTOR Axis.

Lenah S BinmahfouzHaifa AlmukadiAbdulmohsen J Alamoudi Ali M El Halawany Hossam Mohamed AbdallahMardi M AlgandabyGamal Abdallah Mohamed Sabrin Ragab Mohamed IbrahimFaraj A AlghamdiMajed Al-ShaeriAshraf B Abdel-Naim

Published in: Plants (Basel, Switzerland) (2022)

6-PD protects against testosterone-induced BPH in rats. This can be attributed, at least partly, to its antiproliferative, antioxidant, and anti-inflammatory properties as well as its ability to inhibit activation of the AKT/mTOR axis.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
cell proliferation
anti inflammatory
signaling pathway
high glucose
diabetic rats
oxidative stress
drug induced
smoking cessation