Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry.

Mohamed W AttwaAdnan A KadiHany W Darwish

Published in: Drug design, development and therapy (2020)

Accordingly, we can conclude that LRB is a moderate extraction ratio drug when compared with other tyrosine kinase inhibitors (TKIs). According to our knowledge, the discussed procedure in this study is the first LC-MS/MS analytical method for evaluating LRB metabolic stability.

Keyphrases

liquid chromatography tandem mass spectrometry
simultaneous determination
solid phase extraction
ms ms
healthcare
high intensity
minimally invasive
emergency department
mass spectrometry
drug induced
tandem mass spectrometry
electronic health record