Dysregulation of memory B cells and circulating T follicular helper cells is a predictor of poor immune recovery in HIV-infected patients on antiretroviral therapy.
Yan LiuZhen LiXiaofan LuYi-Qun KuangDeshenyue KongXin ZhangXiaodong YangXiuwen WangTingting MuHu WangYihang ZhangJunyan JinWei XiaHao WuTong ZhangChristiane MoogBin SuPublished in: Journal of medical virology (2023)
Our results suggest that the functions of memory B cells in INRs are dysregulated at the early stage of ART, possibly through disruption of Tfh cell function. The frequency and function of Tfh cells and their subsets are potential predictors of poor immune recovery. This article is protected by copyright. All rights reserved.
Keyphrases
- antiretroviral therapy
- hiv infected patients
- induced apoptosis
- early stage
- hiv infected
- human immunodeficiency virus
- cell cycle arrest
- hiv positive
- hiv aids
- working memory
- endoplasmic reticulum stress
- oxidative stress
- squamous cell carcinoma
- dendritic cells
- regulatory t cells
- radiation therapy
- pi k akt
- sentinel lymph node