Quantitative in vivo mapping of myocardial mitochondrial membrane potential.
Nathaniel M AlpertNicolas GuehlLeon PtaszekMatthieu Pelletier-GalarneauJeremy RuskinMoussa C MansourDustin WootenChao MaKazue TakahashiYun ZhouTimothy M ShoupMarc D NormandinGeorges El FakhriPublished in: PloS one (2018)
We have analyzed the factors affecting the uptake of voltage sensing tracers and developed a minimally invasive method for mapping ΔΨT in left ventricular myocardium of pigs. ΔΨT is computed in absolute units, allowing for visual and statistical comparison of individual values with normative data. These studies demonstrate the first in vivo application of quantitative mapping of total tissue membrane potential, ΔΨT.
Keyphrases
- high resolution
- left ventricular
- minimally invasive
- high density
- heart failure
- oxidative stress
- human health
- mass spectrometry
- magnetic resonance imaging
- acute myocardial infarction
- risk assessment
- electronic health record
- computed tomography
- big data
- mitral valve
- magnetic resonance
- robot assisted
- acute coronary syndrome
- artificial intelligence