The International Family Study of Nonsyndromic Orofacial Clefts: Design and Methods.
Allyn AuslanderRoberta McKean-CowdinDevin FeigelsonFrederick BrindopkeMelissa DiBonaKathy MageeLili ArakakiRijuta KapoorStephanie LyDavid V ContiSylvia RakotoarisonFouzia MahmoudiAlbertina McGregorMelissa GironAngela Rose HernandezThi-Hai-Duc NguyenAnselme MwepuPedro A Sanchez-LaraWilliam MageePublished in: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association (2021)
The International Family Study is the largest case set of NSOFCs with an associated biobank in LMICs currently assembled. The biobank, family, and case-control study now include samples from 8 LMICs where local health care infrastructure cannot address the surgical burden of cleft or investigate causal mechanisms. The International Family Study can be a source of information and may collaborate with local public health institutions regarding education and interventions to potentially prevent NSOFCs.