Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols.

Ben J TicknerSanna KomulainenSanna Turunen Janne Heikkinen Petri Lehenkari Vladimir V Zhivonitko Ville-Veikko Telkki

Published in: RSC advances (2022)

Signal amplification by reversible exchange (SABRE) hyperpolarisation is used to enhance the NMR signals of nicotine and acrolein in methanol-d 4 solutions of electronic cigarette aerosols. Consequently, detection of 74 μM nicotine is possible in just a single scan 1 H NMR spectrum. The first example of an aldehyde hyperpolarised using SABRE is demonstrated and we work towards novel real-world applications of SABRE-hyperpolarised NMR for chemical analysis.

Keyphrases

magnetic resonance
solid state
high resolution
smoking cessation
computed tomography
single cell
label free
water soluble
mass spectrometry
loop mediated isothermal amplification
sensitive detection
contrast enhanced