Genetic profiling of decreased bone mineral density in an independent sample of Caucasian women.
X XiaoD RoohaniQing WuPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2018)
A substantially large percentage of healthy Caucasian women have a high genetic risk of osteoporosis. Weighted GRS was significantly associated with decreased BMD. The contribution of subtype GRS to the BMD variation differs by specific biological pathway and skeletal regions.
Keyphrases
- bone mineral density
- postmenopausal women
- polycystic ovary syndrome
- body composition
- genome wide
- pregnancy outcomes
- african american
- magnetic resonance
- copy number
- cervical cancer screening
- breast cancer risk
- single cell
- magnetic resonance imaging
- gene expression
- type diabetes
- computed tomography
- metabolic syndrome