Friedel-Crafts Type Methylation with Dimethylhalonium Salts.
Sebastian HämmerlingPatrick VoßnackerSimon SteinhauerHelmut BeckersSebastian RiedelPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
The dimethylchloronium salt [Me2 Cl][Al(OTeF5 )4 ] is used to methylate electron-deficient aromatic systems in Friedel-Crafts type reactions as shown by the synthesis of N-methylated cations, such as [MeNC5 F5 ]+ , [MeNC5 F4 I]+ , and [MeN3 C3 F3 ]+ . To gain a better understanding of such fundamental Friedel-Crafts reactions, the role of the dimethylchloronium cation has been evaluated by quantum-chemical calculations.