Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity.
Mohamed AlamirMohammed Abdalla HusseinHeba M AboudMohamed H KhedrMohamed I ZanatyPublished in: Current pharmaceutical biotechnology (2024)
Administration of PTN-NSLs significantly attenuated the levels of glycemic, oxidative stress, and inflammatory biomarkers. The biochemical and PCR findings are aided by histological investigations. Also, the present findings imply that PTN-NSLs might be a promising pharmacological tool for the treatment of obesity-related diseases.
Keyphrases
- oxidative stress
- type diabetes
- insulin resistance
- diabetic rats
- metabolic syndrome
- weight loss
- signaling pathway
- high fat diet induced
- weight gain
- cancer therapy
- high fat diet
- skeletal muscle
- drug delivery
- induced apoptosis
- dna damage
- drug induced
- pi k akt
- high glucose
- ischemia reperfusion injury
- epithelial mesenchymal transition
- combination therapy
- protein kinase
- heat stress