SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Jinyuan LuoTao HeJiayi YangNing YangZongyuan LiYiqiao XingPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)
SIRT1 activation by RSV confers neuroprotection on RGCs in retinal IR injury through the activation of Akt pathway and subsequent suppression of mitochondrial apoptotic pathway. Determination of the effective concentration of intravitreal injection of RSV also provides a theoretical basis for the clinical application of RSV.
Keyphrases
- diabetic retinopathy
- respiratory syncytial virus
- oxidative stress
- respiratory tract
- optical coherence tomography
- induced apoptosis
- brain injury
- cell death
- cell cycle arrest
- cerebral ischemia
- signaling pathway
- ischemia reperfusion injury
- optic nerve
- cell proliferation
- vascular endothelial growth factor
- ultrasound guided
- type diabetes
- adipose tissue
- insulin resistance
- blood brain barrier
- anti inflammatory
- molecularly imprinted
- skeletal muscle