Neuroprotective and Neuromodulatory Effects Induced by Cannabidiol and Cannabigerol in Rat Hypo-E22 cells and Isolated Hypothalamus.

Viviana di GiacomoAnnalisa ChiavaroliGiustino OrlandoAmelia CataldiMonica RapinoValentina Di ValerioSheila LeoneLuigi BrunettiLuigi MenghiniLucia RecinellaClaudio Ferrante

Published in: Antioxidants (Basel, Switzerland) (2020)

The CBD modulates hypothalamic neuromodulators consistently with its anorexigenic role, whereas the CBG effect on the same mediators suggests alternative mechanisms, possibly involving peripheral pathways.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
signaling pathway
brain injury
pi k akt
blood brain barrier
subarachnoid hemorrhage