A Narrative Review of Signaling Pathway and Treatment Options for Diabetic Nephropathy.
Bhupesh Chander SemwalNeha ChauhanJyoti VermaAnkit KumarSonia SinghBhupendra SinghPublished in: Current molecular medicine (2023)
Information was collected from online search engines like, Google Scholar, Web of Science, PubMed, Scopus, and Sci-Hub databases using keywords like diabetes, nephropathy, kidney disease, autophagy, etc. Result: Natural compounds have anti-inflammatory and antioxidant properties and impact various signaling pathways. They ameliorate kidney damage by decreasing oxidative stress, inflammatory process, and fibrosis and enhance the antioxidant system, most likely by activating and deactivating several signaling pathways. This review focuses on the role of metabolic memory and various signaling pathways involved in the pathogenesis of DN and therapeutic approaches available for the management of DN. Special attention is given to the various pathways modulated by the phytoconstituents.
Keyphrases
- signaling pathway
- oxidative stress
- anti inflammatory
- diabetic nephropathy
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- working memory
- diabetic rats
- dna damage
- ischemia reperfusion injury
- type diabetes
- health information
- public health
- social media
- metabolic syndrome
- glycemic control
- skeletal muscle
- heat shock
- machine learning
- network analysis