Plasma extracellular vesicle transcriptome as a dynamic liquid biopsy in acute heart failure.

Priyanka Gokulnath Michail Spanos Helge Immo Lehmann Quanhu Shen Rodosthenis S Rodosthenous Mark D Chaffin Dimitrios Rafail Kalaitzopoulos Emeli Chatterjee Elizabeth Hutchins Guoping LiGeorge DaaboulFarhan RanaAshley Mingyi WangKendall R Van Keuren-Jensen Patrick T EllinorRavi ShahSaumya Das

Published in: medRxiv : the preprint server for health sciences (2023)

responses, lncRNAs within EVs during acute HF may provide insight into potential therapeutic targets and mechanistically relevant pathways. These findings provide a "liquid biopsy" support for the burgeoning concept of HFpEF as a systemic disorder extending beyond the heart, as opposed to a more cardiac-focused physiology in HFrEF.

Keyphrases

acute heart failure
heart failure
ultrasound guided
fine needle aspiration
ionic liquid
liver failure
left ventricular
respiratory failure
drug induced
gene expression
single cell
genome wide
rna seq
atrial fibrillation
aortic dissection
human health
extracorporeal membrane oxygenation
mechanical ventilation