Unsupervised cluster analysis of patients with recovered left ventricular ejection fraction identifies unique clinical phenotypes.
Andrew S PerryFrancis LohLuigi AdamoKathleen W ZhangElena DeychRandi ForakerDouglas L MannPublished in: PloS one (2021)
There is significant clinical heterogeneity among patients with LVrecEF. Clinical outcomes are distinct across phenotype clusters as defined by clinical cardiac characteristics and co-morbidities. Clustering algorithms may identify patients who are at high risk for recurrent HF, and thus be useful for guiding treatment strategies for patients with LVrecEF.
Keyphrases
- ejection fraction
- aortic stenosis
- left ventricular
- machine learning
- end stage renal disease
- newly diagnosed
- single cell
- gene expression
- acute myocardial infarction
- peritoneal dialysis
- coronary artery disease
- genome wide
- hypertrophic cardiomyopathy
- percutaneous coronary intervention
- atrial fibrillation
- aortic valve
- transcatheter aortic valve replacement