Metadherin Promotes Malignant Phenotypes And Induces Beta-Catenin Nuclear Translocation And Epithelial-Mesenchymal Transition In Gastric Cancer.

Di FengXiaoyu YuXing TianHong-Xue MengYang JiangHongTao SongWenQi LiHaoCheng ZhangJingshu Geng

Published in: Cancer management and research (2019)

MTDH overexpression in GC cells is associated with EMT and development of cancer stem cell malignant phenotypes and affects the subcellular translocation of β-catenin. The results warrant investigation of the prognostic value of MTDH in GC and as a therapeutic target.

Keyphrases

epithelial mesenchymal transition
cancer stem cells
induced apoptosis
transforming growth factor
signaling pathway
cell proliferation
cell cycle arrest
gas chromatography
transcription factor
endoplasmic reticulum stress
oxidative stress
cell death
high resolution
simultaneous determination