Cardiotoxicity in breast cancer treatment: What about left ventricular diastolic function and left atrial function?
Ana Teresa TimóteoLuisa Moura BrancoFrederico FilipeAna GalrinhoPedro RioGuilherme PortugalSónia OliveiraRui Cruz FerreiraPublished in: Echocardiography (Mount Kisco, N.Y.) (2019)
During breast cancer treatment, 20% of the patients develop new or worsening diastolic dysfunction, being age the main determinant, suggesting higher impact of chemotherapy in older patients. Contractile left atrial function is also compromised but, in this case, age seems to be protective. Our results support a stricter surveillance in older patients together to eventually adjust chemotherapy regimens.
Keyphrases
- left atrial
- left ventricular
- mitral valve
- atrial fibrillation
- ejection fraction
- hypertrophic cardiomyopathy
- heart failure
- cardiac resynchronization therapy
- aortic stenosis
- acute myocardial infarction
- catheter ablation
- blood pressure
- public health
- end stage renal disease
- oxidative stress
- newly diagnosed
- prognostic factors
- chronic kidney disease
- squamous cell carcinoma
- replacement therapy
- percutaneous coronary intervention
- combination therapy
- chemotherapy induced
- rectal cancer