Amyloid involvement in subcortical regions predicts cognitive decline.
Soo Hyun ChoJeong-Hyeon ShinHyemin JangSeongbeom ParkHee Jin KimSi Eun KimSeung Joo KimYeshin KimJin San LeeDuk L NaSamuel N LockhartGil D RabinoviciJoon-Kyung SeongSoo Hyun Chonull nullPublished in: European journal of nuclear medicine and molecular imaging (2018)
We demonstrated a downward spreading pattern of amyloid, suggesting that amyloid accumulates first in neocortex followed by subcortical structures. Furthermore, our new finding suggested that an amyloid staging scheme based on subcortical involvement might reveal how differential regional accumulation of amyloid affects cognitive decline through functional and structural changes of the brain.