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Diabetes mellitus induced by PD-1 and PD-L1 inhibitors: description of pancreatic endocrine and exocrine phenotype.

Lucien MarchandArnaud ThivoletStéphane DalleKarim ChikhSophie ReffetJulien VouillarmetNicole FabienChristine Cugnet-AnceauCharles Thivolet
Published in: Acta diabetologica (2018)
In the patients presented herein, immunotherapy-induced diabetes was not associated with T1D-related autoantibodies. The hormonal and morphological analysis of the pancreatic glands of these six cases contributes to the understanding of the underlying and probably heterogeneous mechanisms. There is a need to find biomarkers to identify patients at risk to develop these new forms of diabetes at early stages of the process to prevent ketoacidosis and to evaluate preventive strategies.
Keyphrases
  • end stage renal disease
  • type diabetes
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • cardiovascular disease
  • glycemic control
  • metabolic syndrome
  • adipose tissue
  • polycystic ovary syndrome