Defibrotide inhibits antiphospholipid antibody-mediated NET formation and venous thrombosis.
Ramadan A AliShanea K EstesAlex A GandhiSrilakshmi YalavarthiClaire K HoyHui ShiYu ZuoDoruk ErkanChristian LoodPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
This study is the first to demonstrate mechanisms by which defibrotide counteracts neutrophil-mediated thrombo-inflammation inherent to APS.