Authentication Analysis of MT-4 Cells Distributed by the National Institutes of Health AIDS Reagent Program.
Melissa V Fernandez-de CéspedesKrista A Delviks-FrankenberryDavid A ScheiblinChristine HappelVinay K PathakEric O FreedPublished in: Journal of virology (2019)
The MT-4 human T-cell line expresses HTLV-1 Tax and is permissive for replication of an HIV-1 gp41 mutant lacking the cytoplasmic tail. MT-4 cells (lot 150048), distributed by the NIH AIDS Reagent Program (NIH-ARP), were found to be Tax deficient and unable to host replication of the gp41-truncated HIV-1 mutant. These findings, together with short tandem repeat profiling, established that lot 150048 are not bona fide MT-4 cells.
Keyphrases
- induced apoptosis
- antiretroviral therapy
- cell cycle arrest
- human immunodeficiency virus
- hiv infected
- hiv positive
- quality improvement
- hepatitis c virus
- healthcare
- hiv aids
- endothelial cells
- mental health
- signaling pathway
- oxidative stress
- public health
- cell death
- cell proliferation
- pi k akt
- men who have sex with men
- wild type