Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice.
Camille AnsermetGabriel CentenoSylviane LagarrigueSvetlana NikolaevaHikari A YoshiharaSylvain PradervandJean-Luc BarrasNicolas DattnerSamuel RotmanFrancesca AmatiDmitri FirsovPublished in: Acta physiologica (Oxford, England) (2020)
Collectively, these results establish the role of ARG2 in the formation of corticomedullary urea and osmolality gradients and suggest that this enzyme attenuates kidney damage in ischemia-reperfusion injury.