FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes.
Chao ZhuShuang WenJunyong LiHongyu MengJunzhe ZhangKuo ZhaoLing WangYingze ZhangPublished in: Drug design, development and therapy (2021)
Our findings demonstrated that oral administration of FTY720 exerted beneficial effects in CIA mice by inhibiting CD4+ T lymphocyte recruitment to the affected joints. Our data also indicated that FTY720 inhibited TNF-α-induced inflammation by suppressing the AKT/PI3K/NF-κB pathway in MH7A cells.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- signaling pathway
- diabetic rats
- oxidative stress
- rheumatoid arthritis
- high glucose
- high fat diet induced
- drug induced
- cell proliferation
- big data
- pi k akt
- electronic health record
- adipose tissue
- cell cycle arrest
- lps induced
- inflammatory response
- nk cells
- nuclear factor
- wild type