Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients.
Irma ConvertinoMarco TuccoriSara FerraroGiulia ValdiserraEmiliano CappelloDaniele FocosiCorrado BlandizziPublished in: Critical care (London, England) (2020)
Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrimental effects on the quality of care and increased mortality. Social isolation strategies have been implemented worldwide with the aim of reducing hospital pressure. Among therapeutic strategies, the use of immunomodulating drugs, to improve prognosis, seems promising. Particularly, since pneumonia and ARDS are associated with a cytokine storm, drugs belonging to therapeutic classes as anti-IL-6, anti-TNF, and JAK inhibitors are currently studied. In this article, we discuss the potential advantages of the most promising pharmacological approaches.
Keyphrases
- acute respiratory distress syndrome
- healthcare
- mechanical ventilation
- sars cov
- extracorporeal membrane oxygenation
- respiratory failure
- intensive care unit
- emergency department
- quality improvement
- rheumatoid arthritis
- risk factors
- respiratory syndrome coronavirus
- cardiovascular events
- palliative care
- cardiovascular disease
- type diabetes
- drug induced
- chronic pain
- climate change