Circulating tumour cell enumeration does not correlate with Miller-Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy.
Sharon A O'TooleCathy SpillaneYanmei HuangMarie C FitzgeraldBrendan FfrenchBashir MohamedMark WardMichael GallagherTanya KellyCathal O'BrienCarmel RuttleAnna BogdanskaCara MartinDorinda MullenElizabeth ConnollySarah A McGarrigleJohn KennedyJohn J O'LearyPublished in: Breast cancer research and treatment (2020)
Patients with a complete response to NAC still had CTCs present, suggesting enumeration is not sufficient to aid surgery stratification. Additional characterisation and larger studies are needed to further characterise CTCs isolated pre- and post-chemotherapy. Long-term follow-up of these patients will determine the significance of CTCs in NAC breast cancer patients.
Keyphrases
- circulating tumor cells
- neoadjuvant chemotherapy
- locally advanced
- patients undergoing
- transcription factor
- end stage renal disease
- minimally invasive
- newly diagnosed
- lymph node
- single cell
- prognostic factors
- stem cells
- rectal cancer
- cell therapy
- patient reported outcomes
- mesenchymal stem cells
- young adults
- case control
- surgical site infection
- percutaneous coronary intervention