A General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling.

Tabitha T SchemppBlake E DanielsSteven T StabenCraig E Stivala

Published in: Organic letters (2017)

The preparation of substituted azaindolines utilizing a domino palladium-catalyzed Heck cyclization/Suzuki coupling is described. The approach is amenable for the construction of all four azaindoline isomers. A range of functional groups such as esters, amides, ketones, sulfones, amines, and nitriles are all tolerated under the reaction conditions.

Keyphrases

room temperature
molecularly imprinted
electron transfer
molecular docking
mass spectrometry
molecular dynamics simulations