Cured HCV patients with suboptimal hepatitis B vaccine response exhibit high self-reactive immune signatures.

Ming-Ju Zhou Chao Zhang Yuan-Jie Fu Haiyan Wang Yingjie Ji Xia Huang Lin Li Ye Wang Song Qing Yanze Shi Lili Shen You-Yuan Wang Xiao-Yu Li Yuan-Yuan Li Si-Yuan Chen Cheng Zhen Ruonan Xu Ming Shi Fu-Sheng Wang Yongqian Cheng

Published in: Hepatology communications (2023)

Our data suggest that cured HCV patients exhibit persistent perturbations in the adaptive immune system, among which highly self-reactive immune signatures may contribute to a suboptimal hepatitis B vaccine response.

Keyphrases

hepatitis c virus
end stage renal disease
ejection fraction
chronic kidney disease
genome wide
prognostic factors
peritoneal dialysis
electronic health record
big data
gene expression
patient reported outcomes