Insulin and body mass index decrease serum soluble leptin receptor levels in humans.
Christine SommerKjersti G VangbergGunn-Helen MoenDavid M EvansSindre Lee-ØdegårdIngvild K Blom-HøgestølLine SletnerAnne K JenumChristian A DrevonHanne L GulsethKåre I BirkelandPublished in: The Journal of clinical endocrinology and metabolism (2022)
Both BMI and insulin causally decreased serum sOb-R levels. Conversely, intensive exercise and food intake acutely increased sOb-R. Our results suggest that sOb-R is involved in short-term regulation of leptin signalling, either directly or indirectly, and that hyperinsulinaemia may reduce leptin signalling.