A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.
Cameron J ReidMax Laurence CumminsStefan BörjessonMichael S M BrouwerHenrik HasmanAnette M HammerumLouise RoerStefanie HessThomas BerendonkKristina NesporovaMarisa HaenniJean-Yves MadecAstrid BetheGeovana B MichaelAnne-Kathrin SchinkStefan SchwarzMonika DolejskaSteven Philip DjordjevicPublished in: Nature communications (2022)
Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.
Keyphrases
- escherichia coli
- biofilm formation
- klebsiella pneumoniae
- genome wide
- sars cov
- intensive care unit
- magnetic resonance
- antimicrobial resistance
- drinking water
- acute kidney injury
- coronavirus disease
- copy number
- electronic health record
- cystic fibrosis
- computed tomography
- transcription factor
- climate change
- artificial intelligence
- septic shock
- risk assessment
- big data
- genome wide identification
- genome wide analysis
- bioinformatics analysis
- genetic diversity