A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.
Luca MeninJanine WeberStefano VillaEmanuele MartiniElena MasperoValeria CancilaPaolo MaiuriAndrea PalamidessiEmanuela FrittoliFabrizio BianchiClaudio TripodoKylie J WaltersFabio GiavazziGiorgio ScitaSimona PoloPublished in: bioRxiv : the preprint server for biology (2023)
Collective motion of jammed epithelia requires myosin VI activityThe MYO6-DOCK7 axis is critical to restrict the activity of RAC1 in a planar polarized fashionMYO6-DOCK7-RAC1 activation ensures long-range coordination of movements by promoting orientation and persistence of cryptic lamellipodiaMyosin VI overexpression is exploited by infiltrating breast cancer cells.