Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension.
Vivek P JaniM Imran AslamAxel J FenwickWeikang MaHenry GongGregory MilburnDevin NissenIlton Cubero SalazarOlivia HanselmanMonica MukherjeeMarc K HalushkaKenneth B MarguliesKenneth CampbellThomas C IrvingDavid A KassSteven HsuPublished in: bioRxiv : the preprint server for biology (2023)
While there are multiple RV myocyte contractile deficits In HFrEF-PH, clinical indices primarily detect reduced isometric calcium-stimulated force related to deficits in basal and recruitable %DRX myosin. Our results support use of therapies to increase %DRX and enhance length-dependent recruitment of DRX myosin heads in such patients.
Keyphrases
- heart failure
- pulmonary hypertension
- end stage renal disease
- traumatic brain injury
- chronic kidney disease
- ejection fraction
- endothelial cells
- newly diagnosed
- mycobacterium tuberculosis
- binding protein
- depressive symptoms
- smooth muscle
- single molecule
- pulmonary arterial hypertension
- sleep quality
- coronary artery
- physical activity
- patient reported outcomes
- acute heart failure