Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol.

Kannan SridharanAmbritha BalasundaramThirumal Kumar DGeorge Priya Doss C

Published in: Current drug metabolism (2023)

Polymorphisms in CYP2E1, CYP1A2, CYP3A4, and CYP3A5 significantly influence paracetamol's clinical outcomes or binding affinity. Robust clinical studies are needed to identify these polymorphisms' clinical impact on the pharmacokinetics or pharmacodynamics of paracetamol.

Keyphrases

drug induced
liver injury
machine learning
artificial intelligence
anti inflammatory drugs
big data
liver failure
respiratory failure
hepatitis b virus