Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach.
Jason C ChangDeepu AlexMatthew BottKay See TanVenkatraman SeshanAndrew GoldenJennifer L SauterDarren J BuonocoreChad M VanderbiltSounak GuptaPatrice DesmeulesFrancis M BoddGregory J RielyValerie W RuschDavid R JonesMaria E ArcilaWilliam D TravisMarc LadanyiNatasha RekhtmanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Comprehensive NGS allows unambiguous delineation of clonal relationship among NSCLCs. In comparison, standard histopathologic approach is adequate in most cases, but has notable limitations in the recognition of IPMs. Our results support the adoption of broad panel NGS to supplement histology for robust discrimination of NSCLC clonal relationships in clinical practice.