Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery.
Nikolai HuldeZittermann ArminMarcus-Andre DeutschJan F GummertVera von DossowAndreas KosterPublished in: The Thoracic and cardiovascular surgeon (2022)
We investigated whether in patients undergoing off-pump coronary artery bypass grafting surgery a single bolus of 1 g tranexamic acid (TXA) impacts the risk of postoperative delirium using the propensity score matching approach. In 2,757 pairs, the risk of delirium was 4.2% (TXA group) and 5.0% (non-TXA group), with a relative risk in the TXA versus the non-TXA group of 0.83 (95% confidence interval: 0.65-1.07; p = 0.16). There was no significant interaction between TXA administration and renal function on the risk of delirium ( p = 0.12). Data indicate that a single bolus of 1 g TXA does not increase the risk of delirium in patients undergoing off-pump surgery.
Keyphrases
- patients undergoing
- cardiac surgery
- minimally invasive
- coronary artery bypass grafting
- coronary artery bypass
- hip fracture
- percutaneous coronary intervention
- surgical site infection
- coronary artery disease
- acute kidney injury
- electronic health record
- high resolution
- mass spectrometry
- deep learning
- artificial intelligence
- single molecule