Exploiting iron metabolism as a therapeutic vulnerability in glioblastoma.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

In this CCR Translations, we discuss pharmacological ascorbate as a novel therapeutic for glioblastoma. Aberrant iron metabolism in glioblastoma can be assessed noninvasively by MRI and exploited to potentially improve the efficacy of chemoradiotherapy. We contextualize the study's results and discuss the next steps to further develop this paradigm.

Keyphrases

magnetic resonance imaging
climate change
contrast enhanced
regulatory t cells
iron deficiency
radiation therapy
diffusion weighted imaging