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Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.

Hongjie PanXiao-Ping ZhongSunhee Lee
Published in: BMC biochemistry (2016)
Our data revealed that sustained activation of mTORC1 due to defects in TSC1 promotes AMPKα-dependent autophagic flux to maintain cellular homeostasis.
Keyphrases
  • cell death
  • skeletal muscle
  • electronic health record
  • signaling pathway
  • oxidative stress
  • protein kinase
  • endoplasmic reticulum stress
  • single cell
  • big data
  • machine learning
  • deep learning